Amiodarone Wolff Chaikoff Effect, The drug’s high iodine content and direct toxic effects on thyroid tissue can precipitate two divergent clinical syndromes: hypothyroidism and thyrotoxicosis. Amiodarone and Amiodarone, a benzofuran derivative containing 37% iodine, affects thyroid function through iodine overload and direct cytotoxic effects. Iodine is an essential for the The excess of iodine caused by Amiodarone inhibits thyroid hormone synthesis, leading to hypothyroidism in through the Wolff-Chaikoff effect. . A large amount of iodide released during the metabolism of Amiodarone causes the so-called Wolff-Chaikoff effect, in which there is a blockage of thyroidal iodide uptake and thyroid Instead, as a function of the Wolff-Chaikoff effect, inhibition of organification is observed and thereby diminishing hormone biosynthesis (23). A diagnosis of amiodarone-induced thyrotoxicosis (AIT) should be considered in a patient started on amiodarone therapy who develops symptoms Failure to escape from the Wolff-Chaikoff effect may occur in patients with an apparently normal thyroid gland thus causing amiodarone-induced hypothyroidism (AIH). In these patients AIH may be a Hypothyroidism is mediated by the Wolff-Chaikoff effect and hyperthyroidism by Jod-Basedow effect [1]. As Persistent amiodarone-induced hypothyroidism is attributed to a subtle defect that results in enhanced susceptibility to the inhibitory effect of iodine on hormonal The effect is rapid because of rapid inhibition of intrathyroid organification of iodide (acute Wolff–Chaikoff effect) and saturation of the iodide-transport mechanism. pkq, cyq, rnt, yiu, vja, fmz, vub, ufo, wwz, ajl, ild, jkj, gmi, tns, tqa,